Extract and molecular‐based early infant sensitization and associated factors—A PreventADALL study

Background More knowledge about sensitization patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. Objective We aimed determine the prevalence and allergic at 3 months age, explore possible associated factors. Methods From Scandinavian antenatally recruited PreventADALL mother–child cohort, we included 1110 3-month infants with available serum. Sensitization was defined as s-IgE ≥0.1 kUA/L by Phadiatop Infant® (ThermoFisher Scientific) birch, cat, grass, dog, milk, egg, peanut wheat. Further ImmunoCAP analyses ovomucoid, casein, Ara h 1-3, omega-5-gliadin were performed food extract s-IgE-positive children. Maternal ≥ 0.35 Phadiatop® (inhalant allergen mix) and/or Fx5 (food 18-week pregnancy. Results Overall 79 (7.3%) had specific sensitization, many low s-IgE-levels (IQR 0.16–0.81 kUA/L), 78 being sensitized allergens; 41 27 10 peanut, 25 A total 62/78 further analysed, 18 (29%) 1-3 omega-5-gliadin. Eight (0.7%) inhalant allergens. allergens infant odds ratio 3.64 (95% CI 1.53–8.68). Conclusion Already 7% food, mostly without detectable molecules, <1% infants’ sensitization.